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GERALD WEISSMANN, M.D.; ELECTRA D. XEFTERIS, M.D.

AMA Arch Intern Med. 1959;103(6):957-961.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

While effective in a variety of rheumatic conditions, phenylbutazone has incurred the reputation of being a relatively toxic drug. Purpura,¹ depression of erythropoiesis,² aggravation of bleeding ulcers,¹ and Stevens-Johnson syndrome³ have been reported consequent to its administration, but by far the most alarming complications of phenylbutazone therapy have been agranulocytosis and, more frequently, leukopenia.¹ The nature of white cell damage produce by this agent has not been previously elucidated, although structural similarities to aminopyrine have caused speculation as to analogous leukotoxicity.

Certain drugs, when added to the serum of patients with leukopenia, will cause agglutination of autologous and homologous white blood cells. Gold and aminopyrine particularly have been mentioned in this regard.⁴ It is the purpose of this communication to add phenylbutazone to this list and to examine the relationship that the drug bears to aminopyrine in leukoagglutination activity. We have studied a patient whose serum caused agglutination of homologous . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Departments of Medicine and Hematology, The Mount Sinai Hospital; formerly Assistant Resident in Medicine, now Fellow of the Arthritis and Rheumatism Foundation, Study Group for Rheumatic Diseases, New York University College of Medicine (Dr. Weissmann) and Resident in Hematology (Dr. Xefteris).

Footnotes
Submitted for publication Aug. 16, 1958.

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