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Clinical Features and Connective Tissue Patterns

A. E. ANDERSON, Jr., M.D.; ALVAN G. FORAKER, M.D.

AMA Arch Intern Med. 1959;103(6):966-973.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Eosinophilic granuloma may be defined briefly as a chronic inflammatory disorder of unknown etiology characterized primarily by the presence of histiocytes and eosinophils. General awareness of this disease may be said to be a consequence of two almost simultaneous but independent studies which appeared in 1940,^1,2 although Mazzitello³ mentions the existence of less well-appreciated earlier descriptions. After 1940 a series of papers appeared in considerable number, and a clinical and pathological spectrum has gradually evolved.

Histologically, many of the cases have shown apparent transitions with two other disorders, namely, the Hand-Schüller-Christian syndrome and Letterer-Siwe disease. So consistent have these similarities been that it is now generally conceded that all three diseases represent variants or interrelated expressions of the same fundamental malady. The over-all group has been designated as "Histiocytosis X" by Lichtenstein,⁴ histiocytosis referring to the common cell type or histological hallmark and X indicating the need . . . [Full Text PDF of this Article]

Author Affiliations
Jacksonville, Fla.

From the Research Laboratory, Baptist Memorial Hospital, and the Departments of Medicine, Duval Medical Center and St. Vincent's Hospital.

Footnotes
Submitted for publication Sept. 29, 1958.

Presented at the Annual Meeting of the Florida Trudeau Society, in Clearwater, Fla., April, 1958.

This investigation was supported by a research grant (H-3255) from the National Heart Institute, U. S. Public Health Service.

Miss Gladys Clark and Mrs. Bette Anderson provided technical assistance. Mr. Gene Nabi aided in preparation of the photomicrographs.

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