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ROBERT G. PETERSDORF, M.D.; IVAN L. BENNETT, Jr., M.D.

AMA Arch Intern Med. 1959;103(6):991-1001.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Fever may be defined as any abnormal elevation in body temperature. Although abnormal elevation of body temperature is sometimes a reflection of normal physiological processes, such as exercise, consumption of food, menstruation, and pregnancy,¹ it is properly designated as fever only when it is a manifestation of disease. The investigations of Wunderlich² first placed clinical thermometry on a firm basis, and his findings formed the nucleus of a large body of empiric knowledge concerning fever as a manifestation of disease. Despite the fact that much is known about fever from the clinical point of view, the mechanisms responsible for this important physiological disturbance are poorly understood. It is the purpose of this report to summarize the results of experimental studies on the pathogenesis of fever.

Relationship of Fever to Tissue Injury

Many widely diversified pathological entities are associated with fever. Among these are infections; "collagen-vascular diseases," such as . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

From the Department of Medicine and Pathology, The Johns Hopkins University School of Medicine and The Johns Hopkins Hospital.

Footnotes
Submitted for publication Oct. 21, 1958.

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