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CryptococcosisFurther Observations and Experiences with Amphotericin B
WILLIAM J. MARTIN, M.D.;
DONALD R. NICHOLS, M.D.;
HENDRIK J. SVIEN, M.D.;
JOHN A. ULRICH, Ph.D.
AMA Arch Intern Med. 1959;104(1):4-14.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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Infections due to Cryptococcus neoformans (Torula histolytica) continue to create diagnostic and therapeutic problems. Since our previously reported experience with this type of infection,1 we have studied eight additional patients with cryptococcosis. Five of these patients have had meningoencephalitis and have been treated with the antibiotic, amphotericin B. Detailed reports of the diagnostic difficulties encountered in these five patients and their response to therapy with amphotericin B seem indicated.
Report of Cases
CASE 1.
—A 43-year-old industrialist first came to the Mayo Clinic in July, 1955, complaining of episodic semiconsciousness and occipital headache of seven months' duration. In April, 1955, he had been hospitalized elsewhere, and culture of his spinal fluid had yielded C. neoformans.
Physical findings at the clinic were within normal limits except for marked obesity. Laboratory data on this and subsequent visits included results of urinalyses and estimations of the concentration of hemoglobin, the number of
. . . [Full Text PDF of this Article]
Author Affiliations
Rochester, Minn.
Section of Medicine (Drs. Martin and Nichols), Section of Neurologic Surgery (Dr. Svien), and Section of Bacteriology (Dr. Ulrich), Mayo Clinic and Mayo Foundation. The Mayo Foundation, Rochester, Minn., is a part of the Graduate School of the University of Minnesota.
Footnotes
Submitted for publication Nov. 25, 1958.
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