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RAPHAEL D. SCHWARTZ, M.D.; MURRAY BRODOFF, M.D.; GEORGE L. COHN, M.D.; HOWARD M. SPIRO, M.D.

AMA Arch Intern Med. 1959;104(2):260-263.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The successful use of topical steroid therapy in diseases of the eye, skin, and joints has led to an evaluation of the effect of cortisol enemas in idiopathic ulcerative colitis. Observations from this laboratory have implied negligible absorption of cortisone from the rectum in ulcerative colitis. and so a relative absence of side-effects was to be anticipated.¹ Truelove and others have reported encouraging results with rectal hydrocortisone in ulcerative colitis.^2,3 This report represents an attempt to define the type of patient in whom such therapy might be most helpful.

Methods

All 16 patients studied had the diagnosis of ulcerative colitis confirmed by sigmoidoscopy and x-ray examination at either the Grace-New Haven Community Hospital or the West Haven Veterans Administration Hospital. Stool examinations were performed to exclude amebiasis, bacillary dysentery, and other causes of diarrhea; many patients had received antiamebic therapy on an empirical basis. Table 1 illustrates an . . . [Full Text PDF of this Article]

Author Affiliations
New Haven, Conn.

From the Department of Internal Medicine, Yale University School of Medicine.

Footnotes
Submitted for publication Dec. 4, 1958.

Supported in part by U. S. Public Health Grants C-2578 and A-1785.

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