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Penicillin Sensitivity of Gram-Negative Enteric BacilliSuccessful Treatment of Urinary Tract Infections
GEORGE K. DAIKOS, M.D.;
MARIA ATHANASIADOU, M.D.
AMA Arch Intern Med. 1959;104(3):378-384.
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Of the Gram-negative flora, those really sensitive to penicillin are the Neisseriae, which behave chemotherapeutically the same way as the Gram-positive cocci. If we modify our definition of sensitivity and go to higher concentrations than those usually attained in the body after the clinical dosage forms of penicillin, we may encounter a few strains that are inhibited by moderate concentrations of the antibiotic. There are a few reports in the literature of septicemias caused by Gram-negative resistant bacteria (as Proteus) that were cured by huge doses of penicillin.2-5,9
The minimal inhibitory concentrations for those strains were mostly 10µg.-20µg. per milliliter. Strains requiring higher concentrations have been correctly considered as extra resistant. Attention has been drawn to the sensitivity of Proteus, and the strains of Proteus mirabilis have been proven more sensitive than the other strains.1,6,7,9
The concentrations used in those studies were very low (3µg. per milliliter). The same results
. . . [Full Text PDF of this Article]
Author Affiliations
Athens, Greece With the Technical Assistance of Phopho Kouskoumvekaki
From the Alexandra Hospital and the Department of Clinical Therapeutics of the Athens University School of Medicine. Assistant Professor of Medicine, Athens University School of Medicine, Senior Visiting Physician, Department of Clinical Therapeutics, Alexandra Hospital (Dr. Daikos); Bacteriologist, Chief of Bacteriology Research Laboratory, Department of Clinical Therapeutics, Alexandra Hospital (Dr. Athanasiadou).
Footnotes
Submitted for publication Jan. 6, 1959.
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