This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (9)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

M. RACHMILEWITZ, M.D.; Y. STEIN, M.D.; ARONOVITCH, M.Sc.; N. GROSSOWICZ, Ph.D.

AMA Arch Intern Med. 1959;104(3):406-410.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It has been shown that liver-cell damage caused by various agents (viral,^1-4 chemical,⁵ infiltrating tumor ⁶) is associated with markedly increased levels of cyanocobalamin (vitamin B₁₂) in the blood, which are due to the release of the vitamin from damaged liver cells.

This report deals with observations on cyanocobalamin activity in the serum of patients with severe congestive heart failure associated with hepatomegaly.

Material and Methods

Twenty-eight patients suffering from chronic congestive heart failure due to arteriosclerotic, rheumatic, or congenital heart disease were studied. In all patients marked hepatomegaly was present as well as venous engorgement; in some there was also ascites and peripheral edema. The duration of right heart failure preceding the time of the present examination varied from several months to seven years. Cyanocobalamin was determined mircobiologically with a mutant strain of Escherichia coli, as described previously.⁷,⁸ In some cases, repeated cyanocobalamin determinations were made before and after . . . [Full Text PDF of this Article]

Author Affiliations
Jerusalem

From the Departments of Medicine "B" and Bacteriology, Hebrew University-Hadassah Medical School.

Footnotes
Submitted for publication Nov. 25, 1958.

This work was supported by grants from Hadassah Medical Organization.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?