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LEIF G. SUHRLAND, M.D.; DAVID RUBIN, M.D.; AUSTIN S. WEISBERGER, M.D.; GORDON C. MEACHAM, M.D.

AMA Arch Intern Med. 1959;104(3):411-416.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Oral administration of cyanocobalamin (vitamin B₁₂) and intrinsic factor derived from hog stomach is known to be effective in producing remissions in patients with pernicious anemia in relapse. However, the efficacy of maintenance therapy with such preparations has been more difficult to evaluate. Short-term studies have indicated that satisfactory remission can be maintained on an oral preparation containing both cyanocobalamin and intrinsic factor.¹ Likewise, massive oral doses of cyanocobalamin without intrinsic factor may maintain patients with pernicious anemia in remission.^2-4 Since it has been observed that it may take several months to years for some patients with pernicious anemia to relapse, evaluation of a treatment program should be based upon a long-term study. The purpose of the present report is to compare the effectiveness of an oral preparation with that of parenteral cyanocobalamin in the management of pernicious anemia over a three-year period.

During the observation . . . [Full Text PDF of this Article]

Author Affiliations
Cleveland

Footnotes
Submitted for publication Jan. 2, 1959.

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