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IV. Urinary Lipase in Carcinoma of the Pancreas

MARTIN M. NOTHMAN, M.D.; ALLAN D. CALLOW, M.D.

AMA Arch Intern Med. 1959;104(4):568-573.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In the course of our studies on urinary lipase ^1-3 we presented evidence that a fatsplitting enzyme was present regularly in the urine of man. Concentration of the enzyme ranged from 0.1 to 0.75 units, that is, 0.1 cc. to 0.75 cc. of N/20 sodium hydroxide has been required to titrate liberated fatty acids from a urine-olive oil mixture, incubated for 24 hours to a pink end-point with phenolphthalein. In patients where the values have been found elevated, that is, higher than 1.0 unit, there were symptoms or laboratory findings or both which pointed to pancreatic disease. In patients with carcinoma of the pancreas, however, values for urinary lipase were less than 1 unit. The same patients had normal values for serum and urinary diastase. The finding that the values for urinary lipase did not show any change from the normal in carcinoma of the pancreas was of no help . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Medical and Surgical Departments of the New England Center Hospital and Tufts University Medical School.

Footnotes
Submitted for publication Feb. 24, 1958.

Supported by a grant from the Damon Runyon Memorial Fund for Cancer Research.

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