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Report of a Case with Studies on Serum Haptoglobin Levels

JAMSHID JAVID, M.D.; HERBERT I. HOROWITZ, M.D.; ARNOLD R. SANDERS, M.D.; THEODORE H. SPAET, M.D.

AMA Arch Intern Med. 1959;104(4):628-633.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Myoglobinuria in man may follow muscle injury by direct mechanical trauma and ischemia due to vascular occlusion. Seven reports have appeared of the syndrome associated with muscular dystrophies, and it may appear in epidemic form as "Haff disease." ^1,2 There are, however, cases of myoglobinuria that cannot be attributed to any known underlying disorder. Twenty-one such cases, designated "idiopathic paroxysmal myoglobinuria," have appeared in the literature; the last was reported in 1957.³ There are, undoubtedly, many additional cases that are either not recognized, or not reported. The general aspects of myoglobinuria have been the subject of extensive reviews by Spaet, Rosenthal, and Dameshek⁴; Reiner et al.⁵; Biorck,⁶ and others.

In a recent in vitro study by Javid, Fischer, and Spaet,⁷ comparing the binding of hemoglobin and of myoglobin in plasma, it was demonstrated that myoglobin is not bound by the serum mucoprotein, haptoglobin. Extensive studies by several groups have established . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Department of Hematology, Laboratory Division, Montefiore Hospital.

Footnotes
Submitted for publication Jan. 8, 1959.

This study was supported by Research Grant No. H-2442 (C) of the National Heart Institute, NIH, USPHS.

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