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Importance of Chemical Transmission in Cardiology and Neuropharmacology
RICHARD J. BING, M.D.
AMA Arch Intern Med. 1959;104(4):658-671.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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The evidence for chemical transmission, or for neurohumoral mechanism, as the late Dr. Cannon at Harvard has called it, goes back to Claude Bernard, who observed that fatigue and block produced by curare were localized at the junctions between the nerve fibers and the excitable cell. Very soon after that, in 1877, DuBois-Reymond recognized the possibility of chemical transmission between the nerve cell and the receptor and found that this may be the result of the liberation of a chemical stimulant rather than of an electrical process. After that, it was recognized that some of the actions of the autonomic nervous system could be duplicated by drugs. Probably the first example of this was the finding that muscarine applied to the frog's heart caused a slowing of the rate very similar to that produced by stimulation of the vagus nerve. We all have become familiar with the term "muscarinic action"
. . . [Full Text PDF of this Article]
Author Affiliations
Detroit
From the Department of Medicine, Washington University and the Washington University Medical Service, Veterans Administration Hospital.
Footnotes
Submitted for publication May 25, 1959.
Dr. Bing's present address is Wayne State University College of Medicine.
The original work in this paper was supported by the American Heart Association; Burroughs Wellcome & Company, Inc.; the Life Insurance Medical Research Fund; the Tobacco Industry Research Fund, and U. S. Public Health Service Grant No. H-2678.
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