This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (24)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

II. Short-Term Intravenous Administration of Single and Multiple Antibacterial Agents; Acidosis and Toxic Nephropathy from a Preparation of Intravenous Nitrofurantoin

WILLIAM R. McCABE, M.D.; GEORGE GEE JACKSON, M.D.; HANS G. GRIEBLE, M.D.

AMA Arch Intern Med. 1959;104(5):710-719.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Despite the advent of potent antibacterial agents the frequency of chronic pyelonephritis has not been significantly reduced, and it has remained notably resistant to permanent cure.^1,2 In a prior study, prolonged treatment with a single agent, although sometimes suppressive, was curative as a rule only if the infecting bacteria were eradicated within the first several days after the initiation of treatment.³ Similar results have been observed by others.⁴ Eradication of the primary infecting strain was sometimes followed by the emergence in the urine of a resistant strain or an entirely new species. These circumstances—failure to eliminate the causative organism even after prolonged treatment, mixed infections or emergence of resistant strains, and superinfection with new species during and after treatment—have been suggested as conditions in which a combination of antimicrobial drugs might be indicated.⁵

This investigation was undertaken to determine whether a combination of several antimicrobial agents designed to inhibit the . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the University of Illinois Research and Educational Hospitals and the Department of Medicine, University of Illinois College of Medicine.

Footnotes
Submitted for publication April 16, 1959.

This investigation was supported in part by a research grant E-1949 from the National Institute of Allergy and Infectious Diseases, of the National Institutes of Health, Public Health Service.

The autopsies were performed by Drs. Theodore Downs, A287-58, and Marilyn O'Brein, A239-58, of the Department of Pathology, who also furnished stained sections of the kidneys for microscopical study.

The drugs used in this study were kindly furnished by the following: Chloramphenicol, Parke, Davis & Company, Detroit, Michigan; Nitrofurantoin, Eaton Laboratories, Inc., Norwich, N.Y.; Polymyxin, Burroughs Wellcome & Company, Inc., Tuckahoe, N.Y.; Ristocetin, Abbott Laboratories, North Chicago, Illinois; and Tetracycline, Lederle Laboratories Division, American Cyanamid Company, Pearl River, N.Y.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?