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JERZY DYBICKI, M.D.; OSCAR J. BALCHUM, M.D., Ph.D.; GEORGE R. MENEELY, M.D.

AMA Arch Intern Med. 1959;104(5):802-815.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Therapy for recurrent effusions of the pleural and peritoneal cavities of patients with local or metastatic malignant processes is an important and often difficult clinical problem. Such effusions occur in at least 29% ¹ of such patients, and, if recurrent and large, they can be the most significant factor in their management. Repeated withdrawals of abdominal and pleural fluid are not only trying to the patient but result in depletion of electrolytes and proteins. The intracavitary instillation of radioactive colloidal gold (Au¹⁹⁸) is frequently of distinct benefit in slowing down or halting the accumulation of fluid, even though such therapy is not curative and does not abolish the malignant process.

An artificially induced radioactive isotope in colloid form was administered for therapeutic purposes for the first time in 1944, in Vanderbilt University Hospital. This was molecular iodine colloid made with cyclotron-produced I¹³⁰ and prepared by Paul F. Hahn. . . . [Full Text PDF of this Article]

Author Affiliations
Nashville, Tenn.

Department of Medicine and the Radioisotope Center, Vanderbilt University School of Medicine.; Rockefeller Foundation Research Fellow, Gdansk, Poland (Dr. Dybicki). Assistant Professor of Medicine, University of Southern California School of Medicine, Los Angeles (Dr. Balchum). Associate Professor of Medicine and Director of the Radioisotope Center, Vanderbilt University School of Medicine and Hospital, Nashville, Tenn. (Dr. Meneely).

Footnotes
Submitted for publication June 5, 1959.

This work was supported in part by grants in aid of research from the American College of Chest Physicians, the Don Tobey Fund, the Fowler Fund, and Graduate Training Grant 2A5129, National Institute of Arthritis and Metabolic Diseases, Public Health Service.

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