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GERALD KLATSKIN, M.D.

AMA Arch Intern Med. 1959;104(6):899-902.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The key to progress in our understanding of cirrhosis has been the recognition that the cirrhotic process represents the end-stage of a wide variety of pathological processes of diverse etiology. Accordingly, the term cirrhosis no longer implies a specific clinical or pathological entity but now encompasses a group of diseases that differ not only in etiology and pathogenesis but also in clinical behavior and therapeutic requirements. To review recent developments in our concept of cirrhosis, the topic I have been assigned, would take us into such diverse areas as the morphology of the hepatic changes induced by malnutrition, alcohol, toxins, and infections; the epidemiology, identification, and immunology of viral hepatitis; the biochemistry and histology of collagen formation; the genetics and biological effects of disturbances in the metabolism of galactose, iron, and copper, and many others. Obviously neither time nor my own limitations would permit a comprehensive review of this subject. . . . [Full Text PDF of this Article]

Author Affiliations
New Haven, Conn.

Professor of Medicine, Yale University School of Medicine.

Footnotes
Received for publication July 24, 1959.

Read in the Symposium on Hepatic Diseases before the Joint Meeting of the Section on Experimental Medicine and Therapeutics, the Section on Gastroenterology and Proctology, the Section on General Practice, the Section on Internal Medicine, the Section on Pathology and Physiology, and the Section on Radiology at the 108th Annual Meeting of the American Medical Association, Atlantic City, June 10, 1959.

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