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ROGER W. ROBINSON, M.D.; NORIO HIGANO, M.D.; WILLIAM D. COHEN, Ph.D.

AMA Arch Intern Med. 1959;104(6):908-913.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

There is increasing evidence to suggest that multiple factors, including heredity, occupation, diet, stress, and preexisting hypertension, diabetes mellitus, hypercholesterolemia, and obesity, are involved in the pathogenesis of coronary heart disease. It has also been observed for many years that women have less coronary disease than men. As long ago as 1803, William Heberden recorded that there were only 3 women in nearly 100 patients with pectoris dolor (angina pectoris).¹ In a series of 30,000 autopsies, Clawson found a malefemale ratio of 8:1 among patients with coronary sclerosis without hypertension.² Clinical studies of coronary heart disease have also shown a sex difference, Levy and Boas³ reporting a male-female ratio of 4.9:1, and Master, Dack, and Jaffe⁴ reporting 3.4:1. These studies have confirmed the observation that women have a decreased incidence of coronary atherosclerosis as compared with men.

Even more striking is the rarity of this disease in women under 40 . . . [Full Text PDF of this Article]

Author Affiliations
Worcester, Mass.

From The Research Laboratory and Medical Division, The Memorial Hospital.

Footnotes
Received for publication July 9, 1959.

This work was supported by Grant H-2658, National Heart Institute, National Institutes of Health, and by a grant from the Worcester Area Chapter, Massachusetts Heart Association.

Read in the Symposium on Basic Problems of Coronary Disease Today before the Joint Meeting of the Section on Experimental Medicine and Therapeutics and the Section on Internal Medicine at the 108th Annual Meeting of the American Medical Association, Atlantic City, June 11, 1959.

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