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ELMER L. DeGOWIN, M.D.; ROBERT E. HODGES, M.D.; HENRY E. HAMILTON, M.D.; TITUS C. EVANS, Ph.D.

AMA Arch Intern Med. 1959;104(6):959-965.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

An ultimate objective in the treatment of hyperthyroidism with radioactive I¹³¹ has been to develop a method of selecting for each patient a dose of the isotope which will destroy precisely enough thyroid tissue to produce the euthyroid state. The application of such a method would eradicate the therapeutic sequelae of radiation thyroiditis, thyroid storm, and myxedema. Protraction of the hyperthyroid state would not occur in patients who now require supplementary doses to correct for the inadequacy of the initial attempt.

Although a search for a satisfactory method of dose prediction has been in progress since radioiodine was first used, in 1941, in the Massachusetts General Hospital,⁵ no ideal solution has yet been found. The thyroidal uptake of I¹³¹ can be measured by tracer doses of the isotope, but the mass of the thyroid gland can only be estimated with great error, either by palpation or by . . . [Full Text PDF of this Article]

Author Affiliations
Iowa City; With the Assistance of Other Members of the Thyroid Clinic

From the Department of Internal Medicine, University Hospitals (Drs. DeGowin, Hodges, and Hamilton) and the Radiation Research Laboratory (Dr. Evans), the State University of Iowa.

Footnotes
Received for publication June 23, 1959.

Read before the Section on Internal Medicine at the 108th Annual Meeting of the American Medical Association, Atlantic City, June 9, 1959.

Studies aided by grants from the Iowa Division of the American Cancer Society and the Division of Biology and Medicine of the U.S. Atomic Energy Commission.

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