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Review and Case Reports

DEWEY J. BAILEY, Jr., Capt. U.S.A.F. (MC)

AMA Arch Intern Med. 1960;105(1):13-22.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Quinidine has an established place in the management of certain cardiac arrhythmias, although the toxic effects produced by this drug remain a potential hazard. With the relatively recent advances in determining the plasma concentration of quinidine and the rather specific indications and cautions stressed when this drug is used in clinical practice, the severe toxic reactions can be minimized but probably never will be completely eliminated.

The toxic effects produced by quinidine are varied and unpredictable. This paper will review the cardiotoxic effects and their management, placing special emphasis on the clinical and experimental evidence for the use of molar sodium lactate in combating this disorder. The results of recent animal experiments regarding the pharmacologic action of quinidine will be summarized.

Recently we encountered the problem of severe cardiac depression in two patients while attempting conversion from auricular fibrillation to normal sinus rhythm by the use of quinidine. Dramatic reversal . . . [Full Text PDF of this Article]

Author Affiliations
Senior Resident, Department of Internal Medicine, University of Virginia Hospital.

Footnotes
Submitted for publication June 11, 1959.

Advice and criticism were given by Drs. William Parson and Julian R. Beckwith, of The Department of Medicine, and Dr. D. R. H. Gourley, of The Department of Pharmacology; technical assistance was given by Miss Alice Liggett, Mrs. Carol Kilty, and Mrs. Joyce Young.

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