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By John William Gofman, M.D., Ph.D. Price, $8. Pp. xx+, 353, with no illustrations. Charles C Thomas, Publisher 301-327 E. Lawrence Ave., Springfield, Ill.; Ryerson Press, 299 Queen St. W. Toronto; Black-well Scientific Publciations, 24-25 Broad St., Oxford, England, 1959.

A. C. Corcoran, M.D., Reviewer

AMA Arch Intern Med. 1960;105(1):171-172.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The background of this book is not stated, although it is relevant to its review. Some 10 years ago the author achieved quantitative, differential separation of low-density serum lipoproteins by adjusting the medium to density 1.06 and photographically recording flotation rates during ultracentrifugation. This brilliant technical development was followed by enthusiastic reports that showed a close association between high concentrations of lipoprotein class S_f 12-20 and previous myocardial infarction. Subsequent data extended the correlation to lipoproteins S_f 20-400. The data were numerically expressed by weighing factors as an 'Atherogenic Index,' based on lipoprotein distribution and diastolic pressure. As the author Indicates, this term implies a causal association which is not fully established and which is not essential to this presentation, although he adduces evidence to suggest that it may be valid. His concepts are developed calmly, clearly, and persuasively, with only faint gleams of the contentiousness and . . . [Full Text PDF of this Article]

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