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The Possible Mechanism Involved in Massive Osteolysis: An Experimental Study

L. WHITTINGTON GORHAM, M.D.

AMA Arch Intern Med. 1960;105(2):199-216.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Osseous tissue, as is well known, does not remain static. It is constantly undergoing absorption and replacement. The process probably depends on a balanced activity between osteoblasts and osteoclasts, a chemical balance between Ca and P, changes in lymph or blood flow, and/or upon some other unknown cause. When there are still such gaps in our knowledge of the physiological production and absorption of bone, it is quite evident that there must be considerably more uncertainty as to the exact mechanism involved in pathologic states, when new bone is formed or old bone is resorbed. Osteolysis has been found associated with a great variety of conditions, including infections, trauma, tumors, hyperparathyroidism, gout, the reticuloses, scleroderma, leprosy, syringomyelia, and tabes (the Charcot joint).

In addition to the foregoing, however, there is a strange, very rare, type of osteolysis which is characterized by the complete disappearance of one or more bones. Occasional . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Me.

Footnotes
Submitted for publication July 30, 1959.

Read by title at the 72d Annual Meeting of The Association of American Physicians, May 6, 1959.

This work was supported by a grant from the New York State Chapter of the Arthritis and Rheumatism Foundation.

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