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A Report of Thirty-Seven Cases

E. HUNTER WILSON, M.D.; SAMUEL P. ASPER, Jr., M.D.

AMA Arch Intern Med. 1960;105(2):244-251.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Duffy and Fitzgerald,¹ in 1950, first called attention to the frequent association of x-ray therapy to the thymus gland of infants to the later appearance of thyroid carcinoma. Subsequently many clinical reports have appeared, not only substantiating this association^2-8 but enlarging it to include any early irradiation received about the head and neck. Although these subsequent data have not provided definitive proof that a causal relationship exists between the two, they have indicated a sufficiently high frequency of occurrence to imply guilt by association. A history of previous irradiation, however, has not been found in all children with thyroid cancer,^9-13 and the possible fallacies of drawing too strong inferences of cause and effect between the one and the other have been pointed out.¹³ Duffy¹⁴ has recently summed up his experiences, and the present study, although not supplying unequivocal proof, is in agreement with his conclusion that the bulk of evidence . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

From the Department of Medicine, The Johns Hopkins University School of Medicine and The John Hopkins Hospital. Assistant in Medicine (Dr. Wilson); Associate Professor of Medicine (Dr. Asper).

Footnotes
Submitted for publication May 22, 1959.

Supported in part by a grant from The Maryland Division of The American Cancer Society.

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