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Part I. Tumor Induction by SE Polyoma Virus

E. A. MIRAND, Ph.D.; J. T. GRACE, M.D.; G. E. MOORE, M.D., Ph.D.; D. MOUNT, M.A.

AMA Arch Intern Med. 1960;105(3):469-481.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The discovery of viruses by Iwanowski¹ in 1892 and its confirmation by Beijerinick ² in 1899 led the two French investigators Borrel ^3,4 and Boss ⁵ to postulate that some tumors may be caused by viruses. The first report of a tumor-inducing virus was made in 1908 by Ellerman and Bang ⁶ who discovered the virus of chicken leukosis. Three years later, Rous ^7,8 discovered the viruses causing chicken sarcoma and osteochondrosarcoma.

In 1932, Shope ^9,10 found that a fibroma in rabbits was caused by a virus, and discovered a virus causing infectious papilloma in rabbits. The following year, Furth¹¹ classified chicken leukosis as erythroblastosis and myeloblastosis, and showed that it was transmissible by cell-free filtrates. In 1936, Bittner ¹² made his fundamental discovery of the virus that induces mammary tumors in mice. Two years later, Lucké ¹³ demonstrated the viral etiology for a kidney carcinoma in the . . . [Full Text PDF of this Article]

Author Affiliations
Buffalo

Roswell Park Memorial Institute, Buffalo.

Footnotes
Submitted for publication Aug. 31, 1959.

This investigation was supported in part by grants from the U.S.P.H. Service, Jane Coffin Childs Fund, and John A. Hartford Foundation.

We would like to acknowledge the assistance of Dr. Albert R. Shadle, Leslie Davis, Helen Fox, Edward Dywinski, Albert Mirand, and of the following Summer Fellows—William Zenosky and Douglas King.

This report is written at the request of the editor and is based in part on a recent exhibit at the 1959 American Medical Association Convention at Atlantic City. It was entitled "The Study of Viruses in Cancer," by E. A. Mirand, D. T. Mount, G. E. Moore, J. T. Grace, and J. E. Sokal.

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