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Mechanisms Used by Unsaturated Fats, Nicotinic Acid, and Neomycin: Excretion of Sterols and Bile Acids

GRACE A. GOLDSMITH, M.D.; JAMES G. HAMILTON, Ph.D.; O. NEAL MILLER, Ph.D.

AMA Arch Intern Med. 1960;105(4):512-517.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Recent studies have shown that various dietary regimens and many pharmacologic agents influence serum-lipid concentrations in man. Ingestion of diets high in unsaturated fat¹ or administration of neomycin ² or large doses of nicotinic acid³ usually cause a decrease in the levels of cholesterol and other lipids in serum. Little is known of the mechanisms responsible for the effects of these dissimilar agents. One mechanism which could lead to a decrease in serum-cholesterol concentration would be an increase in fecal excretion of sterols and bile acids, the latter being the principal endproducts of cholesterol metabolism. This possibility is the subject of the present report. Human subjects were maintained on controlled diets high in saturated or unsaturated fat and were given neomycin or nicotinic acid during part of each experimental period. Fecal excretion of sterols and bile acids were determined with methods developed in our laboratory.

Methods

Methods for . . . [Full Text PDF of this Article]

Author Affiliations
New Orleans

Footnotes
Submitted for publication Sept. 30, 1959.

Published in Transactions of Association of American Physicians, Vol. LXXII, 1959.

Nutrition-Metabolism Unit, Department of Medicine Tulane University School of Medicine, New Orleans, Louisiana.

These studies were aided by grants from the Nutrition Foundation, the National Live Stock and Meat Board, and the U.S. Public Health Service (Grant H-4150).

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