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Radioisotopic Study of Anemia in Chronic Renal Disease
PATRICK A. RAGEN, M.D.;
ALBERT B. HAGEDORN, M.D.;
CHARLES A. OWEN, Jr., M.D.
AMA Arch Intern Med. 1960;105(4):518-523.
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The anemia accompanying chronic renal disease has been attributed primarily to a decreased total erythrocytic mass.1 Although the majority of anemic patients with chronic renal disease have azotemia, there is apparently no direct correlation between the anemia and the degree of retention of urea or any other known substance.2 Measurements by means of differential agglutination and radioisotopes have shown that most patients with chronic renal disease, especially those in a relatively stable state, have erythrocytes with normal survival times. Some patients, particularly those in a terminal state, may have an increased rate of hemolysis, although it is of a degree insufficient to produce anemia if the bone marrow is capable of a normal response to the erythropoietic stimulus of the increased hemolysis.3-9 The production of erythrocytes as measured with radioiron (Fe59) appears to be decreased in chronic renal disease.10-12 In the current study of both the destruction and production of
. . . [Full Text PDF of this Article]
Author Affiliations
Rochester, Minn.
Footnotes
Submitted for publication Oct. 2, 1959.
The Mayo Foundation, Rochester, Minnesota, is a part of the Graduate School of the University of Minnesota.
Abridgement of portion of thesis submitted by Dr. Ragen to the Faculty of the Graduate School of the University of Minnesota in partial fulfillment of the requirements for the degree of Master of Science in Medicine. Fellow in Medicine, Mayo Foundation (Dr. Ragen); Section of Medicine, Mayo Clinic (Dr. Hagedorn); Section of Clinical Pathology, Mayo Clinic (Dr. Owen).
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