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ATTALLAH KAPPAS, M.D.; WILLIAM SOYBEL, M.D.; PAUL GLICKMAN, M.D.; DAVID K. FUKUSHIMA, Ph.D.

AMA Arch Intern Med. 1960;105(5):701-708.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

This is a report of studies on the pyrogenic action of a series of steroid metabolites in man. The chemical prototype for this form of biological activity is the hormonal derivative, 3-hydroxyetiocholane-17-one. This compound, whose capacity to provoke fever in humans was first reported in 1956,^1-3 represents the first pure substance of known chemical structure and of physiologic origin having consistent pyrogenic action in man. The present studies indicate that this thermogenic activity extends to a number of steroid metabolites derived from adrenocortical and gonadal hormones. Certain aspects of the structural basis of this action are described and the effects of in vivo metabolic transformations on the fever-producing activity of these hormone derivatives are noted.

Methods

The following steroids were tested for pyrogenic activity in man: 3-hydroxyetiocholane-17-one; etiocholane - 3,17 - dione; 3 - acetoxyetiocholane -17-one; 3,11β-dihydroxyetiocholane-17-one; 3-hy-droxypregnane-20-one; 3-acetoxypregnane-20-one; pregnane-3,20-dione; pregnane-3a,20a-diol; 21-hy-droxypregnane-3,20-dione; 3-hydroxypregnane-11, 20-dione; 3,17-dihydroxypregnane-20-one; and 3, 17,21 -trihydroxypregnane-11,20-dione. Steroids . . . [Full Text PDF of this Article]

Author Affiliations
Chicago; New York

From the Department of Medicine and Argonne Cancer Research Hospital (operated by The University of Chicago for the United States Atomic Energy Commission), The University of Chicago (Dr. Kappas, Dr. Soybel, Dr. Glickman), and the Sloan-Kettering Institute for Cancer Research, New York (Dr. Fukushima).

Footnotes
Submitted for publication Nov. 9, 1959.

Presented, in part, at the 72nd Annual Meeting of The Association of American Physicians, Atlantic City, N.J. May 5, 1959.

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