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CHEVES McC. SMYTHE, M.D.; C. FORD RIVERS, M.D.; R. M. ROSEMOND, M.D.

AMA Arch Intern Med. 1960;105(6):899-904.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The role of chronic pyelonephritis in the causality of contracted kidney and uremia and its association with hypertension became widely appreciated with the appearance of the papers of Longcope¹ and Weiss and Parker² 20 years ago. It has been assumed usually that the hypertension was secondary to the pyelonephritis rather than that the reverse relationship might be true. However, common as pyelonephritis is, hypertensive vascular disease is even commoner. The postulate that the hypertensive kidney might be more susceptible to pyelonephritis finds support in a number of experimental observations,^3-5 but most strongly in that of De Navasquez⁶ who demonstrated that scarred kidneys were much more apt to become infected when exposed to a challenging bacteremia. As one of many possible approaches to the problem of comparing susceptibilities of hypertensive and nonhypertensive persons to pyelonephritis, a group of hypertensives was compared with a group of carefully matched controls for incidence of . . . [Full Text PDF of this Article]

Author Affiliations
Charleston, S.C.

From the Department of Medicine, Medical College of South Carolina. Supported by a grant from the South Carolina Heart Association and the Saul Alexander Renal Research Fund. John and Mary R. Markle Scholar in and Assistant Professor of Medicine, Medical College of South Carolina (Dr. Smythe). Trainees in Cardiology, National Institutes of Health, and South Carolina Heart Association (Dr. Rivers and Dr. Rosemond).

Footnotes
Submitted for publication Aug. 22, 1959.

This study was initiated with the help of Dr. John A. Boone. Mr. Frank Cordle of the Department of Bacteriology was helpful with all aspects of the urinary bacteriology. Dr. F. M. McCorkle and Dr. C. L. Williams assisted with the collection of data from the patients. Miss Anna Chrisanthis lent technical aid.

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