This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (6)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Effect on Adrenal Cortical Secretory Activity in Normal Subjects

ALEXANDER ULLOA; MATTIE C. GAUTNEY; HOWARD L. HOLLEY; S. RICHARDSON HILL, Jr.

AMA Arch Intern Med. 1960;105(6):914-920.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Similarities between the anti-inflammatory effects obtained from salicylate and glucocorticoid therapy in rheumatic diseases have led to speculation as to a common mode of action of these two substances. Metabolic studies using current laboratory procedures have, however, often produced conflicting results. Data have been reported supporting the concept that salicylates stimulate the pituitary-adrenal axis in man. In other studies these data have not been confirmed and, indeed, appear to have been contradicted. Some investigators have reported an increase in the urinary reducing steroids and no change in neutral 17-ketosteroids after salicylate therapy.^1-3 Others have reported a significant decrease in the urinary 17-hydroxycorticosteroid excretion with a slight decrease in 17-ketosteroid excretion in individuals who have been given large doses of salicylates.⁴ Other reports have shown no significant alteration in either urinary 17-ketosteroids ^5-7 or 17-hydroxycorticosteroids ^6,7 following salicylate administration.

In many of the earlier studies in man, massive . . . [Full Text PDF of this Article]

Author Affiliations
Birmingham, Ala.

From the Department of Medicine and University Hospital, University of Alabama Medical Center and the Medical Service, Veterans Administration Hospital, Birmingham, Ala.; Trainee of the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, United States Public Health Service (Dr. Ulloa).

Footnotes
Submitted for publication Sept. 4, 1959.

These studies were supported by funds from the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, United States Public Health Service.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?