This Article  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Annals of the New York Academy of Sciences, 80: 551-1045, 1959. Edited by E. A. Zeller. Price, not given. Pp. 495, with illustrations. New York Academy of Sciences, 2 E. 63d St., New York 21, 1959.

Dr. Henry Ball, Reviewer

Arch Intern Med. 1960;106(1):155-156.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Several years ago it was observed that iproniazid (nicotinic isopropylhydrazide) used in the treatment of tuberculous patients produced a euphoria in those who were depressed. This chance observation opened a whole realm of study. Iproniazid is now recognized not only as an antibiotic but as one of a large class of psychostimulant or psychoenergizers. These drugs, together with the tranquilizers, have had vast effects on psychiatry. Other and later serendipitous observations have given iproniazid and similar agents a role in diseases more commonly recognized as organic.

Many of the psychostimulants act as inhibitors of the enzyme monoamine oxidase (MAO), and it is this general property which is the subject of the present volume. Epinephrine, norepinephrine, histamine, dopamine, and serotonin are examples of biologically active monoamines normally oxidized by MAO. Increased rabbit brain stem concentrations of serotonin and norepinephrine result from treatment with even a single dose of iproniazid. If epinephrine . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?