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HERBERT R. BRETTELL, M.D.; JERRY K. AIKAWA, M.D.; GERALD S. GORDON, M.D.

Arch Intern Med. 1960;106(1):57-63.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Chlorothiazide (Diuril), a nonmercurial diuretic agent with the chemical formula 6-chloro-7- sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide, has been shown clinically to be effective in the treatment of hypertension and various disease states associated with retention of water and electrolytes.^1,2 Because the chemical method for assaying chlorothiazide is too insensitive for accurate measurements, little is known about the metabolism of this compound in human beings following its administration in pharmacologic doses. Beyer,³ using chlorothiazide tagged with radioactive carbon (C¹⁴), has determined plasma and blood levels of the compound in dogs, and has found them comparable to the chlorothiazide levels obtained by colorimetric assay. Preliminary studies on human subjects indicated that C¹⁴-labeled chlorothiazide is not metabolized to any great extent and that its excretion is rapid; hence it was felt that the compound could be used without danger in human beings. In the present study it was employed in an effort to delineate the behavior of . . . [Full Text PDF of this Article]

Author Affiliations
Denver, With the Technical Assistance of Dale R. Harms

From the Department of Medicine, University of Colorado School of Medicine, Denver.

Footnotes
Submitted for publication Sept. 18, 1959.

C14-chlorothiazide was supplied by Merck Sharp & Dohme on allocation from the U.S. Atomic Energy Commission.

Established Investigator of the American Heart Association (Dr. Aikawa); U.S.P.H.S. Research Fellow (Dr. Gordon).

This work was supported in part by contract No. AT(11-1)-282 between the University of Colorado and the U.S. Atomic Energy Commission, and in part by a grant-in-aid from Merck Sharp & Dohme.

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