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Sequential Changes Evoked by Chlorothiazide in Hypertensive Patients
CATHEL MACLEOD, M.B.;
HARRIET P. DUSTAN, M.D.;
IRVINE H. PAGE, M.D.
Arch Intern Med. 1960;106(3):316-320.
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Enhanced responsiveness to ganglioplegic drugs occurring during short-term treatment with chlorothiazide has been attributed to increased vasomotor tone evoked by oligemia.1 Diuretic-induced oligemia also seems responsible for increased depressor responses to trimethapan (Arfonad) and decreased pressor responses to norepinephrine.2 Chlorothiazide alone can lower arterial pressure in some hypertensive patients,1-3 and this effect may result from a decrease of plasma volume. This report describes the oligemic and antihypertensive effects of the diuretic in hypertensive patients receiving the drug for varying periods. The results support the suggestion 1 that decreases of arterial pressure observed during short-term diuretic therapy result from decreases of plasma volume and not from a specific antihypertensive effect.
Methods
Studies were performed in 17 hypertensive patients hospitalized in the Research Ward of the Cleveland Clinic Hospital. Fifteen received a 100 mEq. sodium diet, and two—who had previously suffered from congestive cardiac failure—continued to take a 55
. . . [Full Text PDF of this Article]
Author Affiliations
Cleveland
From the Research Division of the Cleveland Clinic Foundation and the Frank E. Bunts Educational Institute.
Footnotes
Submitted for publication Feb. 8, 1960.
Supported, in part, by a grant (H-96) from the National Heart Institute, National Institutes of Health.
Dr. Macleod's present address: c/o Bank of New Zealand, No. 1 Queen Victoria Street, London, E.C. 4, England.
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