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Hemagglutination in Hepatic Disease
W. PAUL HAVENS, Jr., M.D.
Arch Intern Med. 1960;106(3):327-334.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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A major obstacle in the development of a specific diagnostic test for viral hepatitis has been the failure to adapt hepatitis viruses to animals, embryonated eggs, and cultures of a wide variety of tissues. This has forced reliance largely on human serum and feces as the only proven possible sources of antigen, the strength of which cannot be determined by any practical means now available. However, in spite of the obvious difficulties inherent in the problem, the search for an immunologic test has continued through the past two decades, resulting in the description of a considerable array of tests that utilize the techniques of complement fixation, precipitin reaction, collodion-particle agglutination, hemagglutination, and the intradermal injection of materials suspected of containing virus. A number of antigens, including serums and extracts of liver, spleen, and feces of patients in the acute phase of disease, extracts of normal tissues, and allantoic fluid obtained
. . . [Full Text PDF of this Article]
Author Affiliations
Philadelphia
From the Departments of Microbiology and Medicine, Jefferson Medical College, Philadelphia.
Footnotes
Submitted for publication Dec. 31, 1959.
Read at the 72nd Annual Meeting, The Association of American Physicians, May 5, 1959.
This investigation was carried out under the sponsorship of the Commission on Viral Infections of the AFEB and was supported by funds provided by the Office of The Surgeon General, Department of the Army, under Contract No. DA-49-193-MD-2079.
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