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ARMAND J. QUICK, Ph.D., M.D.

Arch Intern Med. 1960;106(3):335-340.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Hemophilia is one of the oldest known hereditary diseases and, therefore, has been a rich source of information for genetics. The reports in the older literature must, however, be interpreted with caution, because until recently the diagnosis of hemophilia was often uncertain and sometimes even erroneous. With the development of more definitive tests to study hemophilia and to differentiate it from other bleeding conditions, investigation of various aspects of the disease, especially that of genetics, can now be undertaken with greater assurance of accuracy. The object of the present study is to probe the evidence for the probability that hemophilia may arise de novo, i.e., by mutation.

Methods

The tests which were employed were the same as those described in the recent study of hemophilia B.¹ Additional procedures and preparation of reagents were carried out as previously outlined.² In most instances the cases selected for this investigation have . . . [Full Text PDF of this Article]

Author Affiliations
Milwaukee

From the Department of Biochemistry, Marquette University School of Medicine, Milwaukee.

Footnotes
Submitted for publication Jan. 26, 1960.

This work was supported by a grant (H1612-C13) from the National Heart Institute, National Institutes of Health, United States Public Health Service.

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