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Report of Twelve Cases with Bone Marrow Findings

RICHARD G. FARMER, M.D.; TALBERT COOPER, M.D.; CHRIS A. PASCUZZI, M.D.

Arch Intern Med. 1960;106(4):483-495.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Biochemical and biophysical studies in recent years have demonstrated a steadily widening spectrum of diseases and clinical syndromes related pathogenetically to abnormalities at the molecular level. Such deviations may be hereditary or acquired. Prominent in the latter category are disorders most commonly resulting in "dysproteinemia"—qualitative or quantitative abnormalities of the serum globulin fraction.

The clinical significance of the presence of cold-precipitable serum globulins in various disease states has received considerable attention, and improved laboratory methods and increased clinical awareness suggest that such abnormal serum proteins may be present more frequently than previously recognized and may provoke the patient's presenting symptoms.

History

In 1933, Wintrobe and Buell¹ noted that the serum of a 56-year-old patient with multiple myeloma formed a viscid layer when it was cooled to 4 C and a suspension of white material developed which dissolved when the serum was warmed to room temperature. This patient had . . . [Full Text PDF of this Article]

Author Affiliations
Rochester, Minn.

Footnotes
Submitted for publication Jan. 18, 1960.

Fellow in Medicine. Mayo Foundation (Dr. Farmer); Section of Medicine (Dr. Cooper) and Section of Clinical Pathology (Dr. Pascuzzi), Mayo Clinic and Mayo Foundation. The Mayo Foundation is a part of the Graduate School of the University of Minnesota.

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