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WALTER L. PALMER, M.D.

Arch Intern Med. 1960;106(6):786-796.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The purpose of this paper is to discuss certain factors considered causal in thepathogenesis of peptic ulcer.

Basic Role of Peptic Digestion

The clinical evidence ¹ of the basic role of peptic digestion may be summarized briefly: chronic peptic ulcer occurs only in those portions of the digestive tract exposed to the action of acid gastric juice, and it occurs only in persons whose stomachs secrete acid; its alleged occurrence with persistent achlorhydria is not well documented, although acute and chronic ulcer may occur in patients with low secretory patterns and with transitory achlorhydria. Peptic ulcers invariably heal if the achlorhydria lasts 3 months or longer.^2,3

The experimental evidence for this concept begins with the demonstration by Claude Bernard ⁴ that acid gastric juice is able to digest the leg of a living frog. Modern studies date from the demonstration by Williamson and Mann⁵ in 1923 that transplantation of . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

Footnotes
Submitted for publication July 20, 1960.

The Richard T. Crane Professor of Medicine, The University of Chicago.

The Frank Billings Lecture, read before the Section on Internal Medicine at the 109th Annual Meeting of the American Medical Association, Miami Beach, June 15, 1960.

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