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ELIOT CORDAY, M.D.; HENRY JAFFE, M.D.; DAVID W. IRVING, M.D.

Arch Intern Med. 1960;106(6):809-815.

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The inverse relationship of lipemia and the body metabolism has been established.^1-9 Hurxthal, in 1934, demonstrated that, within limits, the blood cholesterol level reflects the thyroid activity.⁹ Thyroid deficiency is accompanied by an elevated blood cholesterol level, while in hyperthyroidism, the blood cholesterol level is usually below normal. There are many studies which suggest a relationship between the incidence of arteriosclerosis and hypercholesterolemia.^10-12 The search for hypocholesterolemic agents which might prevent arteriosclerotic narrowing of the blood vessels has been exhaustive and frustrating. While it has long been recognized that desiccated thyroid will reduce blood cholesterol levels in the hypercholesterolemic patient, the amount of thyroid which must be administered is of such a magnitude that it often induces a strong calorigenic or adrenergic effect. It is also difficult to administer thyroxin in sufficient amounts to lower the hyperlipemia without the induction of adverse effects such as palpitation due . . . [Full Text PDF of this Article]

Author Affiliations
Los Angeles

Footnotes
Submitted for publication July 20, 1960.

Institute for Medical Research.

This study was presented at the Joint Session of the Sections of Internal Medicine and Experimental Medicine and Therapeutics at the 109th Annual Meeting of the American Medical Association, Miami Beach, June 14, 1960.

Assistant Clinical Professor of Medicine, University of California School of Medicine, Co-Chief, Cardiac Clinic, Cedars of Lebanon Hospital (Dr. Corday); Clinical Professor of Radiology (Therapeutic), University of Southern California, Director of Radiation Therapy, Cedars of Lebanon Hospital (Dr. Jaffe); Research Fellow, Ventura County Heart Association, California (Dr. Irving).

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