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Use of Metaraminol and Comparison with Other Vasopressor Agents

LEWIS C. MILLS, M.D.; IGNATIOS J. VOUDOUKIS, M.D.; JOHN H. MOYER, M.D.; CHARLES HEIDER, M.D.

Arch Intern Med. 1960;106(6):816-823.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Although several vasopressor drugs are available for the treatment of shock, many are characterized by one or more undesirable properties. During the last several years in this hospital most of these agents have been used in patients with shock of various etiologies. These observations indicated that metaraminol was an effective drug for the treatment of shock, and that side-effects were infrequent. Therefore, further laboratory studies were done, and an additional group of 67 patients with shock resulting from various causes were studied.

Methods

In the experimental procedures the following drugs were studied: mephentermine (Wyamine), metaraminol (Aramine), phenylephrine (Neosynephrine), levarterenol (norepinephrine, B.P.; Levophed), epinephrine, and methoxamine (Vasoxyl). Epinephrine was included in these studies only for comparative purposes, since its use in the clinical treatment of hypotensive shock is contraindicated. In the renal studies standard techmiques were used to measure glomerular filtration rate and renal plasma flow.¹ Cerebral blood flow was . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

Department of Internal Medicine, Hahnemann Medical College and Hospital.

Footnotes
Submitted for publication July 20, 1960.

Presented before the Joint Session of the Sections on Internal Medicine and Experimental Medicine and Therapeutics at the 109th Annual Meeting of the American Medical Association, Miami Beach, June 13-17, 1960.

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