This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (23)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

ALFRED SOFFER, M.D.; TAFT TORIBARA, Ph.D.; DOMINIC MOORE-JONES, M.D.; DONALD WEBER, M.D.

Arch Intern Med. 1960;106(6):824-834.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It is not surprising that metal binding may become a valuable technique in the management of cardiac arrhythmias. The ease with which serum calcium is bound by the chelating agents such as edathamil disodium (EDTA) and the prominent though poorly understood place that the calcium ion has in myocardial function made the application of chelation in cardiac malfunction inevitable. Dramatic responses to such induced hypocalcemia have been explained by a direct action of edathamil upon the heart¹ or by reduction of serum calcium ions.² Experimental evidence suggests that decrease in extracellular calcium may enhance an influx of potassium into myocardial cells by altering permeability of the cell membrane.³ Since calcium may potentiate the action and toxicity of digitalis, immobilization of calcium ions by chelation appealed to clinicians as an antidote for hearts poisoned by overdigitalization.⁴ It has been suggested that calcium binding could be used to ascertain the degree of . . . [Full Text PDF of this Article]

Author Affiliations
Rochester, N.Y.

From the Cardiopulmonary Laboratories of the Rochester General Hospital and the Department of Radiation Biology of the University of Rochester School of Medicine and Dentistry.

Footnotes
Submitted for publication July 20, 1960.

Read before Joint Meeting of the Sections on Internal Medicine and on Experimental Medicine and Therapeutics at the 109th Annual Meeting of the American Medical Association, Miami Beach, June 14, 1960.

Chief of Cardiopulmonary Laboratories, The Rochester General Hospital (Dr. Soffer); Associate Professor of Radiation Biology (Analytical Chemistry), Department of Radiation Biology of the University of Rochester School of Medicine and Dentistry (Dr. Toribara); Fellow in Cardiology, The Rochester General Hospital (Dr. Moore-Jones); The Rochester General Hospital (Dr. Weber).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?