This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (5)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Summarization

ROBERT H. WILLIAMS, M.D.

Arch Intern Med. 1961;107(1):69-74.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Basic Considerations

Ketogenic and Antiketogenic Factors.—

The main ketones of the body are acetoacetate, acetone, and β-hydroxybutyrate, formed from acetoacetyl CoA in the liver. They are either excreted in the urine or oxidized, mainly by extrahepatic tissue. Whereas the body can utilize a large amount of ketone for energy, it is limited to approximately 1,500 calories per day, and consequently, when more ketones are formed than are oxidized or excreted, ketosis develops. The 2 major factors leading to ketosis are: (1) decreased glucose oxidation, and (2) increase in supply of fat to the liver. A high fat intake, particularly when accompanied by a very low carbohydrate and protein intake, is conducive to ketosis. Due to the marked decrease in glucose utilization found in diabetes, there is a pronounced tendency for ketosis. Among the factors promoting lipolysis and, consequently, ketosis, are epinephrine, levarterenol, growth hormone, corticotropin, glucosteroids (in diabetics), thyroxin, starvation, . . . [Full Text PDF of this Article]

Author Affiliations
SEATTLE

Department of Medicine, University of Washington School of Medicine.

Footnotes
Submitted for publication June 6, 1960.

Aided by Grant A-2456, National Institute of Arthritis and Metabolic Diseases, United States Public Health Service.

Presented at the First Ames Symposium on Ketosis held at the Presbyterian-St. Luke's Hospital, Chicago, March 2, 1960.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?