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Special Reference to Hemorrhage

KEITH A. MANLEY, M.R.C.P.; ALAN P. SKYRING, M.R.A.C.P.

Arch Intern Med. 1961;107(2):182-203.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

There is increasing awareness of the importance of heritable diseases in medical practice. Individually, most of the diseases with a clearly defined pattern of inheritance are rare, but as a group they make up an appreciable proportion of the cases with which we have to deal. Some of them affect the alimentary tract, and an awareness by the doctor of their manifestations and genetic implications is of importance in the management of the patient and his family. In other gastrointestinal diseases environmental factors are of major importance, and although genetic factors contribute, no clear pattern of inheritance is evident. Peptic ulceration²² and gastric cancer³⁹ may be mentioned as examples of the latter group.

The patient suffering from recurrent gastrointestinal bleeding of uncertain origin presents a perplexing problem, and the cases to be described will illustrate some of the distinctive features which may assist the internist when confronted . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

Present Address: 182 Sheen Road, Richmond, Surrey, England (Dr. Manley); Gastro Intestinal Clinic, Royal Prince Alfred Hospital, Sydney, Australia (Dr. Skyring).; From the Division of Medical Genetics, Department of Medicine, Johns Hopkins University School of Medicine, and The Joseph Earle Moore Clinic, Johns Hopkins Hospital, Baltimore 5, Md.

Footnotes
Submitted for publication April 8, 1960.

This investigation was carried out during the tenure by one of us (K.A.M.) of a Postdoctoral Fellowship (HF 9321) from the National Heart Institute, United States Public Health Service.

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