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CAPT. NORMAN M. KAPLAN, USAF (MC)

Arch Intern Med. 1961;107(2):212-224.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

An elevated glucose tolerance curve is widely accepted as indicative of the presence of diabetes mellitus.^1,2 Caution has been advised, however, in assuming that an elevated response to a glucose load is, in itself, proof of the existence of this disease in patients with fasting normoglycemia.^3,4 Uncertainty has arisen primarily because the oral tolerance test lacks specificity. Almost always abnormal in patients with diabetes, the test is frequently abnormal in nondiabetics as well. Thus, the incidence of a "diabetic" response to oral glucose in a random population sample was 15 times the estimated frequency of diabetes in the general population.⁵ Only between 20% and 30% of subjects with normal fasting levels but elevated curves developed overt diabetes or fasting hyperglycemia during 5- to 30-year follow-up studies.^6-9 Just as many reverted to normal as became diabetic.⁹

The diagnostic unreliability of the oral test has been attributed, . . . [Full Text PDF of this Article]

Author Affiliations
BETHESDA, MD.

From the Department of Medicine, USAF Hospital, Lackland, USAF Aerospace Medical Center (ATC), Lackland Air Force Base, Texas.

Footnotes
Submitted for publication March 2, 1960.

This paper represents the personal viewpoints of the author and is not to be construed as a statement of official Air Force policy.

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