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Use in Advanced Breast Cancer

ROLLAND LOWE, M.D.; ALFRED A. DE LORIMIER, JR., M.D.; GILBERT S. GORDAN, M.D.; LEON GOLDMAN, M.D.

Arch Intern Med. 1961;107(2):241-244.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Recent reports have aroused considerable interest in fluoxymesterone,^* an orally effective, highly potent androgen, for the treatment of advanced breast carcinoma.^1-7 Because its exact antitumor efficacy in breast carcinoma was uncertain and had not been studied with simultaneous controls, we attempted an objective comparison of the effects of fluoxymesterone with those of testosterone propionate in a random series of patients who had received no previous hormonal therapy.

Fluoxymesterone differs from testosterone in having a methyl group in the 17- position (as does methyltestosterone), a fluorine atom in the 9- position, and a hydroxyl group in the 11-β position (Figure).

Method of Study

Selection and Classification of Patients.—

All patients seen in the Advanced Breast Tumor Clinic with recurrent, inoperable, or metastatic carcinoma of the breast, including inflammatory carcinoma, were admitted to the study if they had had no hormonal therapy for breast cancer, were postmenopausal, and had . . . [Full Text PDF of this Article]

Author Affiliations
SAN FRANCISCO

From the Departments of Medicine and Surgery, University of California School of Medicine, San Francisco.

Footnotes
Submitted for publication Feb. 12, 1960.

This investigation was aided by Grant CY-3489 from the National Institute of Health, U.S. Public Health Service, Department of Health, Education, and Welfare, and by a grant from the Upjohn Company. It was carried out under the auspices and with the assistance of the Cooperative Breast Cancer Group of the Cancer Chemotherapy National Service Center. The fluoxymesterone was supplied as Halotestin by the Upjohn Company, Kalamazoo, Mich.

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