This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (11)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

DANIEL B. STONE, M.B. (LOND.); JUDITH G. JEWEL, M.D.

Arch Intern Med. 1961;107(3):372-374.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Despite the fact that Thorn and his associates¹ have given several thousand infusions of corticotropin (ACTH) to patients with a great variety of disease, they observed untoward reactions in 6 patients only. Five of these had Addison's disease. Our experience is much less extensive. In our hospital from 1950 through 1958, medical residents gave corticotropin diagnostically to 17 patients suspected of having adrenocortical insufficiency. The patients did not receive 9--fluorohydrocortisone. Two of the 17 died under circumstances which we believe must be attributed to the use of corticotropin.

Report upon Patients

A 65-year-old man with generalized blastomycosis appeared chronically but not seriously ill. There was weakness, anorexia, nausea, slight pigmentation, and hypotension. He was given 20 units of corticotropin gel intramuscularly for 2 days. It was thought that the collection of urine had been incomplete, so the test was recommended one day later. Eight hours after the fourth dose . . . [Full Text PDF of this Article]

Author Affiliations
IOWA CITY

From the Department of Internal Medicine and the University Hospitals of the State University of Iowa College of Medicine.

Footnotes
Submitted for publication Aug. 27, 1959.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?