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Report of Two Patients

THOMAS C. MERIGAN, JR., M.D.; ROBERT E. HAYES III, M.D.

Arch Intern Med. 1961;107(3):389-394.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Hypercalcemia is a frequent complication of multiple myeloma. In a large series, 28% of reported cases had a serum calcium over 15 mg. % on at least one determination.¹ We have recently had experience with two patients and wish to present them as illustrating certain aspects of this clinical state and its treatment.

Both Myers in his review of the treatment of hypercalcemia in malignancy² and Adams et al. in their review of the management of multiple myeloma³ have noted the dangers of extreme hypercalcemia and have described the use of corticosteroid therapy. The neurologic and cardiac responses to extreme hypercalcemia are profound and lifethreatening. In addition, the effects of hypercalcemia on the kidney (i.e., osmotic diuresis, hyposthenuric polyuria, and renal failure) and on the gastrointestinal tract (i.e., anorexia, nausea, and vomiting) tend to increase the elevation of serum calcium. Corticosteroids have had a consistent and reproducible . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

Assistant Resident in Medicine (Dr. Merigan), and Intern in Medicine (Dr. Hayes), Second and Fourth (Harvard) Medical Services, Boston City Hospital.; From the Thorndike Memorial Laboratory and Second and Fourth (Harvard) Medical Services, Boston City Hospital, and the Department of Medicine, Harvard Medical School.

Footnotes
Submitted for publication April 14, 1960.

Aided, in part, by grant (A-1833) from the National Institutes of Health.

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