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The ABO Blood Groups and Disease in South Africa

JOSEPH A. BUCKWALTER, M.D.; ALLAN E. KARK, B.Sc.; LLOYD A. KNOWLER, Ph.D.

Arch Intern Med. 1961;107(4):558-567.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Human genetics is regarded by many clinicians as a vague discipline at the periphery of the main stream of medicine, contributing little to medical science or practice. This is related to a dearth of experimental tools and techniques which can be effectively used to study hereditary factors in human disease and to lack of familiarity with those which are available. Controlled animal and plant breeding experiments have given us understanding of genetic mechanisms but may not be directly applied to the human species. Since controlled human breeding experiments are impossible, the human geneticist has had to rely on family pedigree studies. These are of limited value because they are time-consuming, because of difficulty in interpretation, and because results are frequently inconclusive. Such studies are frequently impossible because of social or economic factors.

During the past 5 years evidence has been found of associations between the ABO blood groups and various . . . [Full Text PDF of this Article]

Author Affiliations
IOWA CITY

From the Department of Surgery and the Department of Mathematics and Astronomy, State University of Iowa, and the Department of Surgery, University of Natal, Durban, Union of South Africa.

Footnotes
Submitted for publication April 21, 1960.

This study was supported by grants A-1860 and RG-4777, National Institutes of Health, Bethesda, Maryland.

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