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MARCUS M. REIDENBERG, M.D.

Arch Intern Med. 1961;107(4):578-582.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Bone mineral plays a very important role in body electrolyte and acid-base metabolism. The huge amounts of electrolyte contained in the skeleton are listed in the Table. While the subjects of calcium and phosphorus metabolism and metabolic bone diseases have been well reviewed^1-3 and the concentration of many elements in human bone has been determined,^4,5 the function of bone in sodium, potassium, magnesium, and acid-base metabolism has been neglected. It is the purpose of this review to consider these subjects.

Sodium

The average human adult body contains about 3,000-3,500 mEq. of sodium. Approximately 35%-40% of this, or about 1,400 mEq., exists in the skeleton.^7,9,10 Of the sodium in the adult skeleton, about 30% is rapidly exchangeable with radioactive sodium¹¹ and is therefore in continuous dynamic equilibrium with the extracellular fluid.

Many factors have been shown to change the sodium concentration of bone. As the sodium concentration . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Department of Pharmacology, Temple University School of Medicine.; Postdoctoral Research Fellow, National Heart Institute, United States Public Health Service.

Footnotes
Submitted for publication April 7, 1960.

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