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Changes in Hepatic Function, Carbohydrate Tolerance, and Uric Acid Metabolism

WILLIAM B. PARSONS, JR., M.D.

Arch Intern Med. 1961;107(5):653-667.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Numerous reports have verified reduction of serum cholesterol levels in human hypercholesterolemia by large doses of nicotinic acid (3 to 6 gm. daily). In fact, it has become increasingly apparent that this is the most effective chemotherapeutic agent presently available for this purpose, as indicated by its prominent mention by several participants in the recent symposium on The Significance of Lowered Cholesterol Levels published by the AMA Council of Foods and Nutrition.¹ The program's apparent safety has been mentioned by most investigators, but almost without exception the statements have been based on observations covering periods of one year or less.

Our first 2 years of experience (1956-1958) failed to show any significant alterations in hematologic studies, routine urinalyses, blood glucose, or nonprotein nitrogen levels, or in a battery of liver function tests. Needle biopsies of the liver in 17 patients after more than one year of treatment were reviewed . . . [Full Text PDF of this Article]

Author Affiliations
MADISON, WIS.

From the Jackson Clinic and Foundation.

Footnotes
Submitted for publication Aug. 12, 1960.

Research grants for this study were received from the National Heart Institute (U.S. Public Health Service Grant No. H 3787), American Heart Association, and Wisconsin Heart Association.

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