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Antibacterial Activity in Vitro and in Serum of Patients During Treatment

CLARKE G. McCARTHY, M.D.; MAXWELL FINLAND, M.D.

Arch Intern Med. 1961;107(6):863-871.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The nitrofuran derivative now known by the generic name furaltadone and by the trade name Altafur (laboratory code NF-260) was first introduced in October, 1958, by Kefauver, Paberzs, and McNamara¹ under the name "furmethonol" as a potentially useful agent for peroral treatment of systemic bacterial infections. Since that time there have appeared several papers dealing with its antibacterial action in vitro, particular attention being given to the susceptibility of nearly all strains of Staphylococcus aureus including those resistant to the most widely used antibiotics.^2-9 In January, 1960, Christenson and Tracy¹⁰ published a review of 466 cases treated with this drug by various clinicians and collected by the Medical Department of Eaton Laboratories; of 483 infections diagnosed in these cases, 82% were listed as either cured or improved, and only 8% were listed as failures. About onehalf of all these patients were noted as having first failed to . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital and the Department of Medicine, Harvard Medical School. Dr. McCarthy's present address is Western Montana Clinic, Missoula, Mont.

Footnotes
Submitted for publication Feb. 2, 1961.

Aided by a grant (E-23) from the National Institutes of Health.

With the technical assistance of Clare Wilcox and John H. Yarrows.

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