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SIDNEY H. INGBAR, M.D.

Arch Intern Med. 1961;107(6):932-951.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

As investigative tools become more numerous and complex, and specialized knowledge increases, there arises the hazard that the clinician may lose touch with developments in the basic sciences. Moreover, the physiologist or biochemist may fail to seek those clues to the resolution of basic problems which observation of the sick patient often provides. Therefore, in considering the contributions of basic science to clinical medicine we should recall that the flow of stimuli between these disciplines is not unidirectional; each flourishes in the environment of the other. Thus, while the diagnosis and treatment of disease increasingly rest upon a sound assessment of pathologic physiology, clinical observation continues to serve as a catalyst for the growth of basic insights. Nowhere is this interplay better illustrated than in the evolution of clinical thyroidology. Thus, for example, the basic sciences have furnished powerful goitrogenic agents for the control of thyrotoxicosis. On the other hand, . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

Investigator, Howard Hughes Medical Institute.; From the Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital, and the Department of Medicine, Harvard Medical School.

Footnotes
Submitted for publication Jan. 17, 1961.

The original investigations described herein were supported in part by Research Grant No. A-267 from the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, U.S. Public Health Service, and in part by the Medical Research and Development Board, Office of the Surgeon General, Department of the Army, under Contract No. DA-49-007-MD-412.

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