This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (10)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

CDR WILLIAM McFARLAND, MC; NORMA GRANVILLE, M.D.; ROBERT SCHWARTZ, M.D.; HERMAN OLINER, M.D.; D. K. MISRA, M.D.; WILLIAM DAMESHEK, M.D.

Arch Intern Med. 1961;108(1):23-33.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The therapy of hypoplastic anemia may be said to be far from satisfactory. In addition to blood transfusions, numerous measures have been tried, including corticotropin (ACTH) and the corticosteroids,¹ cobalt,² testosterone,³ and splenectomy.⁴ In some cases, one or another of these measures proves to be beneficial, but in most, few if any lasting effects are noted. During the past 3 years our laboratory has been investigating the use of bone marrow transplantation as a therapeutic measure in this disease. The purpose of this paper is to report the results of this study.

Materials and Methods

Patient Material.—

Thirty-seven cases of hypoplastic anemia were observed. All patients under study had a disorder characterized by: (1) severe pancytopenia, (2) hypoplasia of the bone marrow with at least 50% replacement of the normal marrow hematopoietic cells by fat, (3) the absence of splenomegaly, and (4) the absence of other . . . [Full Text PDF of this Article]

Author Affiliations
USN; BOSTON

From the Blood Research Laboratory, Pratt Diagnostic Clinic-New England Center Hospital and the Department of Medicine, Tufts University School of Medicine.; Formerly a Research Fellow in Hematology, Blood Research Laboratory, New England Center Hospital, presently at U.S. Naval Hospital, Bethesda, Md. (CDR McFarland); formerly a Research Fellow in Hematology, Blood Research Laboratory, New England Center Hospital, presently at St. Francis Hospital, Hartford, Conn. (Dr. Granville); Research Associate in Hematology, Blood Research Laboratory, New England Center Hospital, under tenure of a U.S. Public Health Service Fellowship No. HF-7166(C) (Dr. Schwartz); Research Fellow in Hematology, Blood Research Laboratory, New England Center Hospital, under tenure of a U.S. Public Health Service Fellowship No. CF-9754 (Dr. Oliner); Senior Research Fellow in Hematology, Blood Research Laboratory, New England Center Hospital (Dr. Misra); Director, Blood Research Laboratory, New England Center Hospital, Professor of Medicine, Tufts University School of Medicine (Dr. Dameshek).

Footnotes
Submitted for publication Aug. 4, 1960.

Aided by a grant from the U.S. Atomic Energy Commission, Contract AT (20-1)2032.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?