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Effects of Major Surgery on Plasmin-Plasminogen Inhibitors
GEORGE TSITOURIS, M.D.;
SAMUEL BELLET, M.D.;
RALPH EILBERG, M.S.;
LEONARD FEINBERG, Ph.D.;
HERSCHEL SANDBERG, M.D.
Arch Intern Med. 1961;108(2):208-217.
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Although alterations in factors influencing blood coagulation have been extensively studied in various disease states,1,2 much less is known about fibrinolysis, the processes by which fibrin deposits and blood clots are dissolved in the living organism.3 Evidence is accumulating that the latter is one of the fundamental processes in physiology.3,4 In recent years highly purified proteolytic and fibrinolytic enzymes have been used by clinicians in the therapeutic management of thromboembolic disorders.5-8 New and more powerful techniques have also become available to study various phases of clot dissolution.9-16 These developments have stimulated a growing interest in the fibrinolytic processes and their modifications by disease.
Increased fibrinolytic activity has been reported in various pathologic states: conditions of stress, such as acute febrile infections,17 electroshock and anoxia,18 obstetrical complications, such as premature separation of the placenta,19 after pulmonary surgery,4 and after extensive carcinoma of
. . . [Full Text PDF of this Article]
Author Affiliations
PHILADELPHIA
From the Division of Cardiology, Philadelphia General Hospital.
Footnotes
Submitted for publication July 15, 1960.
This paper was written with the technical assistance of Miss Jean Schraeder.
This work was supported by a grant from the Southeastern Heart Association of Pennsylvania and the U.S. Public Health Service, Grant H141 (C8) and H5279.
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