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Antibody Dissociation and Activity

ROBERT S. EVANS, M.D.; MARGARET BINGHAM, M.D.; PETER BOEHNI, M.D.

Arch Intern Med. 1961;108(3):338-352.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

The abnormal red cell destruction in autoimmune hemolytic disease (A. I. H. D.) is attributed to the action of autoantibodies. This concept would be more firmly established if a relationship between the severity of the disease and the amount and variety of the antibodies being formed could be clearly demonstrated. Since most of the autoantibody is adsorbed by the red cells, little is left free in the serum to characterize and quantify. Indeed, the majority of patients with this disorder do not have a sufficient concentration of free serum antibody to be demonstrated by available serological methods.

Antibody attached to red cells may be separated from the whole cell or from the stroma of sensitized cells by several methods that have been found effective in bringing about dissociation of antigen and antibody.^1,2 Antibody recovered in such eluates of red cell stroma may be observed for a variety of . . . [Full Text PDF of this Article]

Author Affiliations
SEATTLE

From the Medical Service of the Veterans Administration Hospital and the Department of Medicine, University of Washington School of Medicine.

Footnotes
Submitted for publication Oct. 7, 1960.

This study was supported by a grant-in-aid from the United States Public Health Service, Project No. A-548 C5.

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